This study aims to investigate the effect of Spirulina algae at a concentration of 1.5%, 3% and 6% on chromosomal abnormalities of bone marrow cells in male albino mice towards the toxicity of benzene. The study included 48 mice divided into two groups: the first group (negative control group = 6 mice) and the group The second contained 42 rats divided into seven groups of 6 rats per group, where the positive control group was injected with benzene at a concentration of 0.2% twice a week diluted with corn oil in the peritoneal cavity, and three interference groups were dosed orally with Spirulina algae powder at a concentration of 1.5%, 3% and 6% once a day. They were injected with benzene at a concentration of 0.2% diluted with corn oil twice a week in the peritoneal cavity, and the last three groups were dosed orally with Spirulina powder only at a concentration of 1.5%, 3%, and 6% once daily. The results of the experiment indicated a significant improvement in chromosomal abnormalities in bone marrow cells in the overlap groups. The three groups (the third, fourth and fifth group) compared to the positive control group. The best results were recorded in the interference group of mice that took Spirulina powder at a concentration of 6% and injected with Gasoline at a concentration of 0.2% (the fifth group), where the rate of chromosomal abnormalities was (0.23 ± 1.98) compared to the positive control, which amounted to (4.03 ± 0.32), while the groups that were dosed orally with Spirulina powder at a concentration of 1.5% and 3% 6% only did not record any significant differences (P˃0.05) compared to the negative control group, so the study recommends using Spirulina powder as a food supplement and an effective substance towards toxicity Gasoline for people exposed to it.