These polyherbal formulations involve a blend of various medicinal plants, and although single herbs are slowly gaining ascendancy over conventional systems of healing, the formulation of polyherbal formulations still involves specific challenges requiring a multidisciplinary approach in which pharmaceutics plays an important role. The challenge that is being universally recognized and is therefore addressed within this context is one of ensuring the optimal design, formulation, and delivery of polyherbal drugs to improve their therapeutic efficacy and bioavailability while maintaining stability and safety. This review comprehensively discusses the imperative aspects related to the development of polyherbal formulations, starting from the selection of herbs with their pharmacological properties followed by the methods of extraction and standardization of the active components. The physicochemical properties encompassed under solubility and particle size play an important role in the discussion and have a resulting impact on both bioavailability and absorption. Stability studies, particularly accelerated testing and estimates of shelf life, are considered fundamental in sustaining the validity of herbal products under various environmental conditions. Quality control of high-quality products also depends on regulatory guidelines and the safety assessment of polyherbal formulations.