The nasal drug delivery system (NDDS) has been employed as an alternative route for the systemic accessibility of medications that are only administered intravenously. This is because of the porous endothelium membrane, huge surface area, high total blood flow, lack of first-pass metabolism, and ease of access. In recent years, there has been a great deal of interest in nasal administration of medications, including different chemical, peptide, and protein pharmaceuticals, for systemic therapy. Following intranasal delivery, drugs are rapidly discharged from the nasal cavity, resulting in rapid systemic drug absorption. Several ways for enhancing the residence period of drug formulations in the nasal cavity, resulting in better nasal medication absorption, are reviewed here.