As the rise in chronic diseases prevalence continues, so does the increasing necessity of polypharmacy, which in turn challenges adherence compliance, drug interactions, and tailored dosing. 3D Printing in Pharmaceutical Industry. This technology of designing and manufacturing multi-drug dosage forms into one single customized unit holds promise. This paper looks at the technological advancements, preparation methods, and clinical utilization of 3D printing in multi-drug delivery with a focus on applying the method to the multifaceted issue of polypharmacy of delivering multiple drugs in one single, specific dose with individualized release profiles. Some of the main chapters include the types of 3D printing methods available in pharmaceuticals, like Fused Deposition Modeling (FDM), Selective Laser Sintering (SLS), and issues related to material selection as well as problems associated with the layering of drugs for controlled release. In addition, pharmacokinetic and pharmacodynamic considerations have also been made whereby the accuracy of 3D printing is associated with drug absorption, metabolism, and interaction in a single dose of medication. The possible future use of such complexity in multi-drug treatments, which could be made for cardiovascular diseases, diabetes, and neurological disorders, could increase benefits for the most vulnerable: the elderly and pediatric populations suffering from polypharmacy problems. Regulatory and ethical aspects are posed to call attention to a need to address quality control and patient safety standards before commercialization of 3D printed multi-drug products. In this regard, the article outlines the directions toward integrating nanotechnology and artificial intelligence for more personalised dosing in the future. The integration of all the research up to date as well as the discussion of the challenges for the future portrays that 3D printing holds the potential of transforming the pharmacy practice into a safer and more effective treatment for patients.