im: This was a cross sectional cadaveric observational study aimed to determine the common sites of division of sciatic nerve in Sudanese cadaveric specimens and also to study the relation of the sciatic nerve to the piriformis muscle. Methods: A total of 50 (48 males and 2 females) dissected cadaveric gluteal and thigh regions were involved and examined unilaterally for the sciatic nerve anatomy course. This involved the site of division of the nerve into its two components, common peroneal and tibial nerves, and its relation to piriformis muscle. Results: Forty six (n=46/50, 92%) of sciatic nerves were observed to be divided after exciting the pelvis and pass below the piriformis muscle, and 4 (n=4/50, 8%) of sciatic nerves were observed to be divided inside the pelvis .The sites of division of sciatic nerve are as followings; 8% inside pelvis, 4% in the gluteal region, 18% in the upper third of the thigh, 34% in the middle third of the thigh, 24% in the superior angle of popliteal fossa and 12% at the center of popliteal fossa. In cases when the sciatic nerve divided inside the pelvis, the common peroneal nerve was observed to pierce the piriformis muscle in 2 cadavers (n=2/4, 50%), and in 2 cadavers (n=2/4, 50%) it was observed to pass below the piriformis muscle. No significant differences between left and right sides specimens were observed. While all tibial nerves pass below the piriformis muscle, when the sciatic nerve is divided inside the pelvis (n= 4/4, 100%). Conclusion: The sciatic nerve site of division in Sudanese population is nearly the same reported in other populations worldwide. Knowledge of the sciatic nerve variations is mandatory for general and plastic surgeons, orthopedic surgeons, and neurosurgeons for better and safe practices.