A REVIEW ON THE DESIGN OF THE FORMULATION FOR A SELFMICROEMULSIFYING DRUG DELIVERY SYSTEM TO INCREASE SOLUBILITY
A significant issue facing the pharmaceutical industry is the poor aqueous solubility of approximately 35–40% of recently introduced drugs. This results in poor dissolution and low bioavailability, which raises intra- and inter-individual variability and lacks dose proportionality. One method for increasing the hydrophobic drug solvency is the self micro emulsifying drug delivery system. Using this method, pharmaceuticals that are insoluble in water may be made soluble in a lipid carrier so they can pass through the membrane. There are increase the drug's solubility and enhance absorption, lipids and surfactants are added. This increases the drug's solubility and also increases its rate of dissolution. SEDDS has the greatest potential for increasing the oral bioavailability of hydrophobic drug. Their dispersion in GI fluid after delivery results in a micro- or nano-emulsified medication that is readily absorbed through lymphatic routes, avoiding the first pass metabolism in the liver. The special capacity of SMEDDS to generate fine oil in water microemulsion with gentle agitation after dilution with aqueous phase makes them isotropic combinations of oil, surfactant, co-surfactant, and drug. In order to successfully address the issue of poorly soluble drug pharmaceuticals. This article provides an overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble drugs
View PDF
